منابع مشابه
Cohesin loops DNA
Cohesin loops DNA T he glue that holds together sister chromatids also compacts meiotic chromosomes, according to Ding et al. on page 499. This cohesin subunit, called Rec8, seems to tie up chromosomes into loops. The role of Rec8, a meiosis-specifi c cohesin subunit, in chromosome architecture was identifi ed by the authors in a fi ssion yeast screen for meiosis mutants. During meiotic prophas...
متن کاملCohesin organizes chromatin loops at DNA replication factories.
Genomic DNA is packed in chromatin fibers organized in higher-order structures within the interphase nucleus. One level of organization involves the formation of chromatin loops that may provide a favorable environment to processes such as DNA replication, transcription, and repair. However, little is known about the mechanistic basis of this structuration. Here we demonstrate that cohesin part...
متن کاملEstablishment of DNA-DNA Interactions by the Cohesin Ring
The ring-shaped structural maintenance of chromosome (SMC) complexes are multi-subunit ATPases that topologically encircle DNA. SMC rings make vital contributions to numerous chromosomal functions, including mitotic chromosome condensation, sister chromatid cohesion, DNA repair, and transcriptional regulation. They are thought to do so by establishing interactions between more than one DNA. Her...
متن کاملThe ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering
Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites. These ATPases are required for cohesin to bind DNA. Cohesin's DNA binding activity is also promo...
متن کاملInterallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA
The cohesin complex (Mcd1p, Smc1p, Smc3p, and Scc3p) has multiple roles in chromosome architecture, such as promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. The prevailing embrace model for sister chromatid cohesion posits that a single cohesin complex entraps both sister chromatids. We report interallelic complementation between pairs of...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1744iti3